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Phoma spp.
(described by Saccardo in 1880 nom. cons.)

Say Me

Taxonomic classification

Kingdom: Fungi
Phylum: Ascomycota
Class: Euascomycetes
Order: Pleosporales
Family: Pleosporaceae
Genus: Phoma

Description and Natural Habitats

Phoma is a dematiaceous filamentous fungus that inhabits the soil and plant material. Phoma species are cosmopolitan in nature and are common plant pathogens. While they are commonly considered as contaminants, Phoma species may rarely cause infections in humans.

Species

The genus Phoma contains several species. Most of the strains isolated from human infections have not been identified to species level. Color of the colony, morphology of the conidia, existence and structure of chlamydospores help in differentiation of the species from eachother [531]. See the list of active names, obsolete names, synonyms, and telemorphs for Phoma spp.

Pathogenicity and Clinical Significance

Phoma species are among the rarely encountered causes of phaeohyphomycosis [700]. The infection commonly develops after a trauma and immunosuppression is a major risk factor for its development. These infections may be cutaneous [160], subcutaneous [131, 383, 875, 2475], corneal [1856], or (rarely) systemic [1580].

Macroscopic Features

Colonies of Phoma grow rapidly. They are flat, spreading, powdery to velvety, and often largely submerged in the medium. From the front, the color is initially white and later becomes olive grey with an occasional tint of pink. From the reverse, it is dark brown to black. Some species (particularly, Phoma cruris-hominis and Phoma herbarum) produce a reddish-purple to yellowish-brown diffusable pigment which is readily visible from the reverse [531, 1295, 2144, 2202].

Microscopic Features

Septate hyphae, pycnidia, conidia, and chlamydospores (for some species only) are visualized. The hyphae are hyaline to brown. Pycnidia are the large, round to pyriform, asexual fruiting bodies which are 70-100 µm in diameter. They are dark in color and bear phialides at their inner lining. Pycnidia have one to several openings (ostioles) on their surface from which the conidia are released outside. Conidia are unicellular, hyaline, and oval-shaped. Each conidium typically has two oil droplets inside. Some Phoma species produce brown chlamydospores that are arranged singly or in chains. These chlamydospores may be unicellular or multicellular and "alternarioid" (resembling Alternaria) in appearence [531, 1295, 2144, 2202].

Histopathologic Features

Phaeoid (brown) hyphae may be observed. See our histopathology page.

Compare to

Alternaria
Chaetomium
Pleurophoma
Pleurophomopsis
Pseudallescheria boydii
Pyrenochaeta

The conidiogenous cells of Phoma are discrete and line the pycnidial cavity. Those of Pleurophoma, on the other hand, are part of the multicellular filaments [531]. Pleurophomopsis differs from Phoma by its thick-walled, multiloculate conidiomata and by producing alpha (short, ellipsoidal) and beta (long, filamentous) conidia [2204]. Phoma differs from Pyrenochaeta by the absence of setae (rigid hair located on the pycnidia).

The perithecia or cleistothecia of Chaetomium or Pseudallescheria boydii are sexual fruiting bodies and bear ascospores inside compared to the pycnidia of Phoma, which are asexual fruiting bodies and bear conidia [2144].

Laboratory Precautions

No special precautions other than general laboratory precautions are required.

Susceptibility

No data are available.

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Phoma spp.
Pycnidium of Phoma spp., conidia develop from within phialides in the lining of the pycnidium.



References

131. Arrese, J. E., C. Pierard-Franchimont, and G. E. Pierard. 1997. Unusual mould infection in the human stratum corneum. J Med Vet Mycol. 35:225-227.

160. Bakerspigel, A., D. Lowe, and A. Rostas. 1981. The isolation of Phoma eupyrena from a human lesion. Arch Dermatol. 117:362-363.

383. Carriere, J., C. Bagnis, E. Gueho, M. O. Bitker, M. Danis, and A. Datry. 1997. Subcutaneous phaeohyphomycosis caused by Phoma cruris-hominis in renal transplant patient. 13th ISHAM Congress, Abstract No.

531. de Hoog, G. S., J. Guarro, J. Gene, and M. J. Figueras. 2000. Atlas of Clinical Fungi, 2nd ed, vol. 1. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.

700. Fader, R. C., and M. R. McGinnis. 1988. Infections caused by dematiaceous fungi: chromoblastomycosis and phaeohyphomycosis. Infect Dis Clin North Am. 2:925-38.

875. Gordon, M. A., I. F. Salkin, and W. B. Stone. 1975. Phoma (Peyronellaea) as a zoopathogen. Sabouraudia. 13:329-333.

1295. Larone, D. H. 1995. Medically Important Fungi - A Guide to Identification, 3rd ed. ASM Press, Washington, D.C.

1580. Morris, J. T., M. L. Beckius, B. S. Jeffery, R. N. Longfeld, R. F. Heaven, and W. J. Baker. 1995. Lung mass caused by Phoma species. Infec Dis Clin Pract. 4:58-59.

1856. Punithalingam, E. 1979. Sphaeropsidales in culture from humans. Nova Hedwigia. 31:119-158.

2144. St-Germain, G., and R. Summerbell. 1996. Identifying Filamentous Fungi - A Clinical Laboratory Handbook, 1st ed. Star Publishing Company, Belmont, California.

2202. Sutton, D. A., A. W. Fothergill, and M. G. Rinaldi (ed.). 1998. Guide to Clinically Significant Fungi, 1st ed. Williams & Wilkins, Baltimore.

2204. Sutton, D. A., W. D. Timm, G. Morgan-Jones, and M. G. Rinaldi. 1999. Human phaeohyphomycotic osteomyelitis caused by the coelomycete Phomopsis saccardo 1905: Criteria for identification, case history, and therapy. J Clin Microbiol. 37:807-811.

2475. Young, N. A., K. J. Kwon-Chung, and J. Freeman. 1973. Subcutaneous abscess caused by Phoma sp. resembling Pyrenochaeta rameroi. Uniques fungal infection occuring in immunosuppressed recipient of renal allograft. Am J Clin Pathol. 59:810-816.



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