Trichosporon loubieri

Colonies are white, dry, and slightly farinose with radial fissures that frequently crack the agar. Colony size is 42-44 mm after 7 days incubation at 25°C.

After 72 hours incubation on cornmeal agar at 25° the yeast produces true hyphae which disarticulate into rectangular arthroconidia. Also present are fusiform giant cells [1270].

This isolate is urease positive and grows at 42°C and on media containing cycloheximide. Type strains were been isolated from mushrooms and a case of cow mastitis. Clinical isolates have been isolated from the sputum of cystic fibrosis patients, from wound infections following a motor vehicle accident, from blood and organs of an ALL patient, and from a polycystic kidney, [1460], [1702].

AMB	CAS	FLU	ITRA	KETO	POSA
0.5 µg/ml=1	16 µg/ml=1	1 �g/ml=1	0.125 µg/ml=1	0.5 µg/ml=2	0.06 µg/ml=1
1.0 µg/ml=1	32 µg/ml=1	4 µg/ml=2	0.25 µg/ml=2	1.0 µg/ml=1

Drug/N	AMB/2	CAS/2	FLU/3	ITRA/3	POSA/1	KETO/3
MIC Range	0.5-1.0	16-32	1.0-4.0	0.125-0.25	0.06	0.5-1.0

* Fungus Testing Laboratory unpublished data (CLSI M27-A2)

PubMed

GenBank

References

1270. Kurtzman, C. P., and J. W. Fell (ed.). 2000. The Yeasts. A Taxonomic Study. Elsevier Scientific B.V., Amsterdam, The Netherlands.

1460. Marty, F. M., D. H. Barouch, E. P. Coakley, and L. R. Baden. 2003. Disseminated trichosporonosis caused by Trichosporon loubieri. J Clin Microbiol. 41:5317-20.

1702. Padhye, A. A., S. Verghese, P. Ravichandran, G. Balamurugan, L. Hall, P. Padmaja, and M. C. Fernandez. 2003. Trichosporon loubieri infection in a patient with adult polycystic kidney disease. J Clin Microbiol. 41:479-482.