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Fusarium proliferatum
(Matsushima) Nirenberg (1976)
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Macroscopic morphology may vary significantly on different media, and descriptions here are based upon growth on potato flakes agar at 25°C with on/off fluorescent light cycles of approximately 12 hours each. Rapid growth. Colonies are initially white, becoming tinged with purple. Reverse colorless to dark purple. Sclerotia may be present and are usually dark blue. Sporodochia rarely formed on PFA but when present are tan to orange. Colonies are usually indistinguishable from those of F. moniliforme [2202], [1630].
Hyphae are septate and hyaline. Conidiophores are medium length, simple or branched. Conidiogenous cells are monophialides and polyphialides. Microconidia are abundant, single-celled and clavate, measure 4.5-10.5 x 1.3-2.5 µm, and are borne from both monophialides and polyphiades in false heads and in chains. Macroconidia may be rare, and are very similar to those see in F. moniliforme. Chlamydoconidia are absent [2202], [1630].
Fusarium proliferatum has been reported as an agent of onychomycosis [996] and superficial suppurative thrombophlebitis [1599]. A disseminated infection was cited by Summerbell, and Herbrecht reported the successful treatment of pneumonia due to this agent in a transplant recipient [2195], [1030]. Fusarium proliferatum differs from F. moniliforme by forming chains of microconidia from both mono- and polyphialides.
| AMB |
ITRA |
VORI |
| 2.0 µg/ml=1 |
1.0 µg/ml=1 |
2.0 µg/ml=1 |
| 4.0 µg/ml=1 |
4.0 µg/ml=1 |
4.0 µg/ml=1 |
| |
>8.0 µg/ml=1 |
8.0 µg/ml=1 |
| Drug/N |
AMB/2 |
ITRA/3 |
VORI/3 |
| MIC Range |
2.0-4.0 |
1.0->8.0 |
2.0-8.0 |
* Fungus Testing Laboratory unpublished data (NCCLS M38-A)
PubMed
GenBank
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References
996. Hattori, N., A. Shirai, Y. Sugiura, W. Li, K. Yokoyama, Y. Misawa, K. Okuzumi, and K. Tamaki. 2005. Onychomycosis caused by Fusarium proliferatum. Br J Dermatol. 153:647-9.
1030. Herbrecht, R., R. Kessler, C. Kravanja, M. H. Meyer, J. Waller, and V. Letscher-Bru. 2004. Successful treatment of Fusarium proliferatum pneumonia with posaconazole in a lung transplant recipient. J Heart Lung Transplant. 23:1451-1454.
1599. Murray, C. K., M. L. Beckius, and K. McAllister. 2003. Fusarium proliferatum superficial suppurative thrombophlebitis. Mil Med. 168:426-7.
1630. Nelson, P. E., T. A. Toussoun, and W. F. O. Marasas. 1983. Fusarium species. An illustrated manual for identification. Pennsylvania State University Press, University Park, PA.
2195. Summerbell, R. C., S. E. Richardson, and J. Kane. 1988. Fusarium proliferatum as an agent of disseminated infection in an immunosuppressed patient. J Clin Microbiol. 26:82-7.
2202. Sutton, D. A., A. W. Fothergill, and M. G. Rinaldi (ed.). 1998. Guide to Clinically Significant Fungi, 1st ed. Williams & Wilkins, Baltimore.
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