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You are here:
The Fungi
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Cryptococcus laurentii
(Kufferath) C.E. Skinner (1950)
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Colonies on Sabouraud dextrose agar at 25°C are cream to pink to tan. The texture is smooth and glossy and frequently slimy allowing the colony to run down the slant or into the lid of Petri dishes stored media side up.
On cornmeal following 72 hours incubation at 25°C, only blastoconidia are present.
This isolate is urease positive but fails to grow at 37°C and gives a negative nitrate reaction [1270]. The type strain was isolated from palm wine. Human cases include disseminated disease to the CNS and skin in an immune competent adult male [2338], fungemia in a neonate [429], fungemia in a cancer patient refractory to fluconazole therapy [143], and infection of the oropharynx in a leukemia patient [203].
| AMB |
FLU |
ITRA |
VORI |
| 0.125 µg/ml=1 |
1.0 µg/ml=1 |
<0.015 µg/ml=1 |
<0.015 µg/ml=1 |
| 0.25 µg/ml=2 |
2.0 µg/ml=3 |
0.03 µg/ml=1 |
0.03 µg/ml=1 |
| 0.5 µg/ml=2 |
4.0 µg/ml=2 |
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0.25 µg/ml=1 |
| 1.0 µg/ml=1 |
16 µg/ml=1 |
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| 4.0 µg/ml=1 |
32 µg/ml=2 |
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| Drug/N |
AMB/7 |
FLU/9 |
VORI/3 |
ITRA/2 |
| MIC Range |
0.125-4.0 |
1.0-32 |
<0.015 -0.25 |
<0.015 -0.03 |
* Fungus Testing Laboratory unpublished data (CLSI M27-A2)
PubMed
GenBank
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References
143. Averbuch, D., T. Boekhout, R. Falk, D. Engelhard, M. Shapiro, C. Block, and I. Polacheck. 2002. Fungemia in a cancer patient caused by fluconazole-resistant Cryptococcus laurentii. Med Mycol. 40:479-484.
203. Bauters, T. G., D. Swinne, T. Boekhout, L. Noens, and H. J. Nelis. 2002. Repeated isolation of Cryptococcus laurentii from the oropharynx of an immunocompromized patient. Mycopathologia. 153:133-5.
429. Cheng, M. F., C. C. Chiou, Y. C. Liu, H. Z. Wang, and K. S. Hsieh. 2001. Cryptococcus laurentii fungemia in a premature neonate. J Clin Microbiol. 39:1608-1611.
1270. Kurtzman, C. P., and J. W. Fell (ed.). 2000. The Yeasts. A Taxonomic Study. Elsevier Scientific B.V., Amsterdam, The Netherlands.
2338. Vlchkova-Lashkoska, M., S. Kamberova, A. Starova, L. Goleva-Mishevska, N. Tsatsa-Biljanovska, V. Janevska, and M. Petrovska. 2004. Cutaneous Cryptococcus laurentii infection in a human immunodeficiency virus-negative subject. J Eur Acad Dermatol Venereol. 18:99-100.
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