Candida lambica

Colonies on Sabouraud dextrose agar at 25°C are tan to yellow, dull, and slightly wrinkled. This isolate grows at 37°C but fails to grow on media containing cycloheximide. The urease reaction is also negative.

On cornmeal following 72 hours incubation at 25°C, abundant, moderately branched pseudohyphae are seen. True hyphae are not formed. This isolate may be differentiated from C. lipolytica by its failure to growth on media containing cycloheximide [1270].

This species has been implicated in bloodstream infections [1774], in infections of patients with hematologic malignancies [1256], and as a cause of arthritis in a patient suffering from alcoholism [2255].

AMB	CAS	5FC	FLU	ITRA	VORI
<0.03 µg/ml=1	0.25 µg/ml=4	<0.125 µg/ml=1	0.25 µg/ml=1	0.03 µg/ml=2	0.03 µg/ml=1
0.06 µg/ml=2			0.5 µg/ml=3	0.06 µg/ml=1	0.25 µg/ml=1
0.125 µg/ml=2			8.0 µg/ml=1
			>64 µg/ml=1

Drug/N	AMB/5	CAS/4	5FC/1	FLU/6	ITRA/3	VORI/2
MIC Range	<0.03-0.125	0.25	<0.125	0.25->64	0.03-0.06	0.03-0.25
MIC₅₀	*	*	*	*	*	*
MIC₉₀	*	*	*	*	*	*

* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)

PubMed

GenBank

References

1256. Kruger, W. H., N. Kroger, B. Russmann, H. Renges, H. Kabisch, and A. R. Zander. 1998. Treatment of mycotic infections after haemopoietic progenitor cell transplantation with liposomal amphotericin B. Bone Marrow Transplant. 22:S10-3.

1270. Kurtzman, C. P., and J. W. Fell (ed.). 2000. The Yeasts. A Taxonomic Study. Elsevier Scientific B.V., Amsterdam, The Netherlands.

1774. Pfaller, M. A., and D. J. Diekema. 2004. Twelve years of fluconazole in clinical practice: global trends in species distribution and fluconazole susceptibility of bloodstream isolates of Candida. Clin Microbiol Infect. 10:11-23.

2255. Trowbridge, J., L. M. Ludmer, V. D. Riddle, C. S. Levy, and W. F. Barth. 1999. Candida lambica polyarthritis in a patient with chronic alcoholism. J Rheumatol. 26:1846-8.