Candida inconspicua Species

Colonies on Sabouraud dextrose agar at 25°C are off-white, dull, and smooth. This isolate grows at 42°C but fails to grow on media containing cycloheximide.

On cornmeal following 72 hours incubation at 25°C, rudimentary to no pseudohyphae are seen. Short chains of ovoid blastoconidia may be seen.

Candida inconspicua is frequently mistaken for Candida krusei by macroscopic appearance. In addition, sugar assimilation studies by commercial kits may give results of both C. krusei and C. inconspicua, however microscopic examination can differentiate the two as C. krusei produces abundant pseudohyphae while C. inconspicua does not [1270]. This isolate may be under-reported due to confusion with C. krusei. This species has been implicated in osteomyelitis [2227], oropharyngeal and esophageal candidiasis in HIV positive patients [158], and from the blood (2) and liver (1) of three patients with hematological malignancies [505].

AMB	5FC	ITRA	VORI
0.125 µg/ml=1	4 µg/ml=1	1.0 µg/ml=1	2.0 µg/ml=1
0.25 µg/ml=1

Drug/N	AMB/2	5FC/1	ITRA/1	VORI/1
MIC Range	0.125-0.25	4.0	1.0	2.0
MIC₅₀	-	-	-	-
MIC₉₀	-	-	-	-

* Fungus Testing Laboratory unpublished data (NCCLS M27-A2)

PubMed

GenBank

References

158. Baily, G. G., C. B. Moore, S. M. Essayag, S. de Wit, J. P. Burnie, and D. W. Denning. 1997. Candida inconspicua, a fluconazole-resistant pathogen in patients infected with human immunodeficiency virus. Clin. Infect. Dis. 25:161-3.

505. D'Antonio, D., B. Violante, A. Mazzoni, T. Bonfini, M. A. Capuani, F. D'Aloia, A. Iacone, F. Schioppa, and F. Romano. 1998. A nosocomial cluster of Candida inconspicua infections in patients with hematological malignancies. J. Clin. Microbiol. 36:792-795.

1270. Kurtzman, C. P., and J. W. Fell (ed.). 2000. The Yeasts. A Taxonomic Study. Elsevier Scientific B.V., Amsterdam, The Netherlands.

2227. Tchang, F. K., and G. L. Gilardi. 1973. Osteomyelitis due to Torulopsis inconspicua. Report of a case. Journal of Bone & Joint Surgery - American Volume. 55:1739-43.