Aspergillus terreus

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Aspergillus terreus

Thom, 1918

Colonies on potato dextrose agar at 25°C are beige to buff to cinnamon. Reverse is yellow and yellow soluble pigments are frequently present. Moderate to rapid growth rate. Colonies become finely granular with conidial production.

Hyphae are septate and hyaline. Conidial heads are biseriate (containing metula that support phialides) and columnar (conidia form in long columns from the upper portion of the vesicle). Conidiophores are smooth-walled and hyaline, 70 to 300µm long, terminating in mostly globose vesicles. Conidia are small (2-2.5 µm), globose, and smooth. Globose, sessile, hyaline accessory conidia (2-6 µm) frequently produced on submerged hyphae.[531, 2202].

This species is noteworthy for its refractoriness to amphotericin B therapy [2202, 2203], [1440, 2367] [2152], [891]. Isolates that are initially white and producing only accessory conidia may be mistaken for Histoplasma capsulatum [2202].

AMB	CAS	ITRA	VORI	POSA	TERB	5FC	MICA	ANID
0.5 µg/ml=1	0.03 µg/ml=14	0.03 µg/ml=2	0.125 µg/ml=2	0.03 µg/ml=5	0.004 µg/ml=2	>64 µg/ml=15	0.03 µg/ml=6	0.03 µg/ml=1
1.0 µg/ml=6	0.06 µg/ml=16	0.06 µg/ml=9	0.25 µg/ml=22	0.06 µg/ml=13	0.015 µg/ml=2
2.0 µg/ml=40	0.125 µg/ml=37	0.125 µg/ml=36	0.5 µg/ml=60	0.125 µg/ml=9	0.03 µg/ml=5
4.0 µg/ml=46	0.25 µg/ml=20	0.25 µg/ml=20	1.0 µg/ml=11		0.06 µg/ml=1
8.0 µg/ml=11	1.0 µg/ml=1	0.5 µg/ml=2			0.125 µg/ml=1
16 µg/ml=1	2.0 µg/ml=2	1.0 µg/ml=3
	4.0 µg/ml=4

Drug/N	AMB/105	CAS/94	ITRA/72	VORI/95	POSA/27
MIC Range	0.5-8.0	0.03-4.0	0.03-1.0	0.25-1.0	0.03-0.125
MIC₅₀	4.0	0.125	0.125	0.5	0.06
MIC₉₀	4.0	0.25	0.25	1.0	0.125

* Fungus Testing Laboratory unpublished data (NCCLS M38-A)

PubMed

GenBank

Delicate, biseriate fruiting head

References

531. de Hoog, G. S., J. Guarro, J. Gene, and M. J. Figueras. 2000. Atlas of Clinical Fungi, 2nd ed, vol. 1. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.

891. Graybill, J. R., S. Hernandez, R. Bocanegra, and L. K. Najvar. 2004. Antifungal therapy of murine Aspergillus terreus infection. Antimicrob. Agents Chemother. 48:3715-3719.

1440. Marr, K. A., T. Patterson, and D. Denning. 2002. Aspergillosis - Pathogenesis, clinical manifestations, and therapy. Infect Dis Clin N Amer. 16:875-894,VI.

2152. Steinbach, W. J., D. K. Benjamin, Jr., D. P. Kontoyiannis, J. R. Perfect, I. Lutsar, K. A. Marr, M. S. Lionakis, H. A. Torres, H. Jafri, and T. J. Walsh. 2004. Infections due to Aspergillus terreus: A multicenter retrospective analysis of 83 cases. Clin Infect Dis. 39:192-198.

2202. Sutton, D. A., A. W. Fothergill, and M. G. Rinaldi (ed.). 1998. Guide to Clinically Significant Fungi, 1st ed. Williams & Wilkins, Baltimore.

2203. Sutton, D. A., S. E. Sanche, S. G. Revankar, A. W. Fothergill, and M. G. Rinaldi. 1999. In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole. J Clin Microbiol. 37:2343-2345.

2367. Walsh, T. J., V. Petraitis, R. Petraitiene, A. Field-Ridley, D. Sutton, M. Ghannoum, T. Sein, R. Schaufele, J. Peter, J. Bacher, H. Casler, D. Armstrong, A. Espinel-Ingroff, M. G. Rinaldi, and C. A. Lyman. 2003. Experimental pulmonary aspergillosis due to Aspergillus terreus: Pathogenesis and treatment of an emerging fungal pathogen resistant to amphotericin B. J Infec Dis. 188:305-319.

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