Help! Please Register

  The Fungi

  Introduction
  Descriptions
  Synonyms
  Image Bank
  Lecture Bank
  Video Bank


  Mycoses

  Introduction
  Human
  Veterinary
  Environmental
   Industrial
  Agricultural
  MSG


  Drugs

  Introduction
  Medical
  Veterinary
  Environmental
   Industrial
  Agricultural


  Laboratory

  Introduction
  Susceptibility
  MIC Database
  Procedures
  Histopathology


  Education &
  Tools

  Introduction
  Abbreviations
  Links
  CME
  Conference
   Highlights
  Bibliography
  Glossary
  Good Books
  Events Calendar


  About Us

  Introduction
  Our Mission
  Editorial Board
  Editorial Staff
  Supporters
  Contributors
  Legal Stuff
  Privacy Policy
  Kudos


  The Fungi

  Introduction
  Descriptions
  Synonyms
  Image Bank
  Lecture Bank
  Video Bank



This page updated:
1/27/2007 9:23:00 AM


DoctorFungus - All Rights Reserved © 2007 Copyright
& Privacy Policy


Site built and designed for doctorfungus by Webillustrated



You are here: The Fungi > Descriptions >


Graphium spp.
(described by Corda in 1837)

Say Me

Taxonomic Classification

Kingdom: Fungi
Phylum: Ascomycota
Class: Euascamycetes
Order:Microascales
Family: Microascaceae
Genus: Graphium

Description and Natural Habitats

Graphium is a filamentous fungus found in soil and plant material. While Graphium may be isolated as an occasional contaminant, its telemorphs, Petriella, Pseudallescheria, and Ceratocystis may cause diseases. Most isolates of Graphium isolated in the clinical laboratory are synanamorphic forms of Pseudallescheria boydii or secondary forms with Scedosporium apiospermum [531, 1295].

Species

The most commonly known species of the genus Graphium are Graphium eumorphum, Graphium fructicola and Graphium putredinis.

Pathogenicity and Clinical Significance

Since one of the telemorphic forms of Graphium is included in genus Pseudallescheria, the pathologies caused by Pseudallescheria boydii in humans are relevant for the genus Graphium as well. In addition, a mixed subcutaneous infection in a captive dolphin has been found to be due to Petriella setifera, the other telemorphic state of Graphium [1814].

Notably, GR135402, a compound with antifungal activity against Candida albicans and Cryptococcus neoformans, has been isolated from a fermentation broth of Graphium putredinis. The antifungal activity of GR135402 is via inhibition of fungal protein synthesis [1193].

Macroscopic Features

Graphium colonies grow moderately rapidly and mature within 7 days. The texture is woolly to cottony. From the front, it is gray in color. From the reverse, the color is pale initially and becomes darker as the colony gets older [1295].

Microscopic Features

Graphium produces hyphae, conidiophores, synnemata, conidia, and rhizoid-like structures. Hyphae are septate and conidiophores are simple, long, and dark in color. Synemmata are bundles of erect hyphae and conidiogenous cells bearing conidia. The conidia are one-celled, oval, and colorless. They form clusters at the apex of each synnema. Rhizoid-like structures may be observed at the base of the synnema. Graphium spp. are recognized by their distinctive, erect, black synnemata, each bearing a single, terminal, ball of one-celled, hyaline conidia produced from annellides [1295].

Histopathologic Features

See our histopathology page for histopathologic features in infections due to Pseudallescheria boydii.

Compare to

Pesotum
Phialographium

Graphium must be distinguished from Pesotum, which produces sympodial conidiophores; and also from Phialographium, which produces phialides.

Laboratory Precautions

No special precautions other than general laboratory precautions are required.

Susceptibility

No data are available for Graphium spp. For susceptibility patterns of the telemorph Pseudallescheria boydii, see our susceptibility database.

Search

PubMed

Nucleotides

GenBank



Graphium spp.
Graphium spp., synanamorph of Pseudallescheria boydii



References

531. de Hoog, G. S., J. Guarro, J. Gene, and M. J. Figueras. 2000. Atlas of Clinical Fungi, 2nd ed, vol. 1. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands.

1193. Kinsman, O. S., P. A. Chalk, H. C. Jackson, R. F. Middleton, A. Shuttleworth, B. A. Rudd, C. A. Jones, H. M. Noble, H. G. Wildman, M. J. Dawson, C. Stylli, P. J. Sidebottom, B. Lamont, S. Lynn, and M. V. Hayes. 1998. Isolation and characterisation of an antifungal antibiotic (GR135402) with protein synthesis inhibition. J Antibiot (Tokyo). 51:41-9.

1295. Larone, D. H. 1995. Medically Important Fungi - A Guide to Identification, 3rd ed. ASM Press, Washington, D.C.

1814. Poelma, F. G., d. G. A. Vries, E. A. Blythe-Russell, and M. H. F. Luykx. 1974. Lobomycosis in an Atlantic bottle-nosed dolphin in the Dolphinarium Harderwijk. Aquatic Mammals. 13:11-15.



  Home | Image Bank | Lecture Bank | Knowledgebase | Site Map | Contact Us |
The Fungi | Mycoses | Drugs |
Laboratory | Education & Tools | About Us

  bttm_banner_indv2_02[1].gif